Benzyl-PEG6-alcohol
CAS No.: 24342-68-5
Cat No.: BP-501459
Purity: ≥95%
4.5 
Benzyl-PEG6-alcohol is a PEG-based linker bearing a benzyl group at one terminus and a terminal primary alcohol at the other, providing a flexible, hydrophilic chain length suitable for PROTAC and related targeted degradation constructs. Structurally, the ether-rich PEG segment acts as a spacing and solubilizing element that can reduce steric interference between the ligand warheads and the recruited E3 ligase-binding moiety, while the benzyl substituent offers a hydrophobic handle for controlled conjugation. The terminal alcohol enables straightforward synthetic functionalization (e.g., conversion to activated carbonate/ester or ether derivatives) to connect the linker to other PROTAC components through stable covalent bonds. In targeted protein degradation research, such PEG linkers are widely used to tune effective intramolecular geometry, improve aqueous compatibility, and support systematic structure–activity relationship studies when optimizing degradation potency and selectivity.
Structure of 24342-68-5
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Benzyl-PEG6-alcohol is a polyethylene glycol based PROTAC linker building block featuring a benzyl-protected alcohol handle and an extended, flexible PEG chain that can enhance solubility and reduce steric bias between the targeting ligand and the E3 ligase recruiter. Its ether-rich backbone supports conformational adaptability typical of PEG linkers used in targeted protein degradation. The points below describe the structure and practical reactivity considerations for PROTAC assembly in research workflows.
Structure: The molecule contains a benzyl-substituted alcohol functionality connected to a linear PEG segment rich in ether linkages. This combination provides a flexible, hydrophilic scaffold with stable C–O and C–C connectivity, supporting conformational freedom and favorable physicochemical behavior in linker-mediated conjugates.
Reactivity: The terminal alcohol enables standard PROTAC linker coupling strategies such as ester or ether formation with activated carboxylic acids or electrophilic leaving groups, typically under mild base or coupling conditions compatible with PEG ethers. Benzyl protection can be removed by hydrogenolysis or oxidative benzyl deprotection approaches when required to expose the reactive alcohol for subsequent conjugation. Common solvents include polar aprotic media for coupling and alcohol-compatible systems for deprotection steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
