Biotin-PEG3-alcohol

 CAS No.: 1263044-40-1  Cat No.: BP-501672  Purity: >97% 4.5  

Biotin-PEG3-alcohol is a biotin-functionalized, short-chain polyethylene glycol (PEG) linker bearing a terminal alcohol, providing a flexible hydrophilic spacer between a biotin tag and a reactive handle. Structurally, it consists of a biotin moiety connected through a three-unit PEG segment to an aliphatic hydroxyl group, enabling solubility enhancement and reduced steric interference in conjugation workflows. In PROTAC and targeted protein degradation research, such linkers are commonly used to append biotin for affinity capture, localization, or assay readouts, while the PEG spacer helps maintain accessibility of both the biotin and the attached partner. The terminal alcohol can be used for further derivatization to generate biotinylated conjugates compatible with downstream coupling chemistries. This product is valuable for constructing biotin-tagged degradation probes, facilitating pull-down/quantification of PROTAC-associated complexes, and improving robustness of biochemical assays by minimizing nonspecific interactions.

Biotin-PEG3-alcohol

Structure of 1263044-40-1

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PROTAC Linker
Molecular Formula
C₁₆H₂₉N₃O₅S
Molecular Weight
375.48
Appearance
Waxy Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
>97%
Appearance
Waxy Solid
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide
Synonyms
(+)-Biotin-PEG3-OH; (+)-Biotin-PEG3-alcohol; Biotin-PEG3-OH
InChI Key
JMPJDHGWKSPEEE-UHFFFAOYSA-N
InChI
InChI=1S/C16H29N3O5S/c20-6-8-24-10-9-23-7-5-17-14(21)4-2-1-3-13-15-12(11-25-13)18-16(22)19-15/h12-13,15,20H,1-11H2,(H,17,21)(H2,18,19,22)
SMILES
C1C2C(C(S1)CCCCC(=O)NCCOCCOCCO)NC(=O)N2

Biotin-PEG3-alcohol is a polyethylene glycol–based linker designed to connect biotin-derived affinity handles to PROTAC architectures. Its flexible PEG segment helps tune linker length, solvation, and conformational freedom, which can improve ternary-complex formation and targeted degradation efficiency in experimental PROTAC workflows. The following points describe its structural features and practical considerations for assembly in PROTAC constructs.

Structure: The linker comprises a biotin moiety tethered through a short, flexible PEG chain terminating in a primary alcohol. It contains ether linkages typical of PEG, amide-free ether connectivity, and multiple heteroatoms that enhance polarity and hydrogen-bonding capacity. Overall, it is conformationally flexible and water-compatible.

Reactivity: The terminal primary alcohol enables standard PROTAC-linker coupling strategies, including conversion to activated derivatives (for example, via esterification or carbonate/halide activation) followed by nucleophilic substitution with compatible partners on the targeting ligand. Typical conditions use mild bases and polar aprotic or alcohol/ether solvents, with reaction progress monitored by chromatography or spectroscopy. PEG ethers generally tolerate aqueous workups, while protecting groups may be selected to preserve sensitive functional groups during assembly.

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-hydroxypyrrolidine-2-carboxamide | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[(1S)-1-(4-ethynylphenyl)ethyl]-4-hydroxypyrrolidine-2-carboxamide | 3-[4-(4-methylpiperazin-1-yl)anilino]piperidine-2,6-dione | (S,R,S)-AHPC-C10-NH2 dihydrochloride | (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-3-(methylamino)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxopropyl]pyrrolidine-2-carboxamide | 2-(2,6-dioxopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-f]isoindole-1,3-dione | N-[(1-Fluorocyclopropyl)carbonyl]-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide | (S,R,S)-AHPC-Me hydrochloride | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-3-(methylamino)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxopropyl]pyrrolidine-2-carboxamide | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[(1S)-1-(4-cyclopropylphenyl)ethyl]-4-hydroxypyrrolidine-2-carboxamide | Biotin-PEG3-alcohol

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