Bis-CH2-PEG2-acid
CAS No.: 2250056-38-1
Cat No.: BP-501029
4.5 
Bis-CH2-PEG2-acid is a bifunctional, short polyethylene glycol–based linker featuring two terminal carboxylic acid groups separated by ethylene glycol units and methylene spacers. Structurally, it provides flexible hydrophilic spacing and two chemically addressable handles for amide or ester formation, enabling controlled conjugation of two PROTAC-relevant fragments such as a ligand for an E3 ligase and a ligand for the target protein. In PROTAC architectures, such linkers help tune the effective distance, relative orientation, and solvation environment between the recruited proteins, which can strongly influence formation of the ternary complex and subsequent ubiquitination-driven degradation. The small PEG length minimizes excessive linker length while still improving aqueous compatibility and reducing unfavorable hydrophobic contacts. As a modular building block, Bis-CH2-PEG2-acid is valuable for rapid synthesis and systematic structure–activity studies, allowing researchers to optimize linker geometry and coupling chemistry in targeted protein degradation experiments.
Structure of 2250056-38-1
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This PROTAC linker, Bis-CH2-PEG2-acid, is designed to provide a hydrophilic, flexible spacer for connecting binding moieties while supporting efficient ternary-complex formation. Its PEG-based architecture helps modulate solubility and conformational freedom, which are key factors in targeted protein degradation workflows. The structure and reactivity considerations below describe how this linker can be used in PROTAC synthesis and subsequent conjugation steps.
Structure: Bis-CH2-PEG2-acid is a PEG-containing, bis-methylene substituted linker bearing carboxylic acid functionality. It features ether linkages within the polyethylene glycol segment, flexible C–O and C–C connectivity, and terminal acidic groups suitable for amide or ester coupling. Overall, it is expected to be highly polar and water-compatible.
Reactivity: The carboxylic acid groups enable standard PROTAC-compatible coupling chemistry, including amide bond formation with amine-bearing warheads or handles. Typical approaches use activated carboxyl derivatives (for example, acid chlorides or carbodiimide-mediated activation) under mild base conditions in polar aprotic solvents. Reaction proceeds via nucleophilic acyl substitution, with careful control of stoichiometry and pH to minimize side reactions and preserve PEG integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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