Name: Boc-NH-PEG2-NH-Boc
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl N-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethyl]carbamate

Synonyms

di-tert-butyl ((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))dicarbamate; 1,8-Di-(tert-butoxycarbonylamino)-3,6-dioxaoctane; 5,8-Dioxa-2,11-diazadodecanedioic acid, 1,12-bis(1,1-dimethylethyl) ester; Bis(2-methyl-2-propanyl) [1,2-ethanediylbis(oxy-2,1-ethanediyl)]biscarbamate; Carbamic acid, N,N'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)]bis-, bis(1,1-dimethylethyl) ester; tert-Butyl N-[2-(2-{2-[(tert-butoxycarbonyl)amino]ethoxy}ethoxy)ethyl]carbamate

Boiling Point

467.5±35.0°C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

IBOKAWABMPUDFK-UHFFFAOYSA-N

InChI

InChI=1S/C16H32N2O6/c1-15(2,3)23-13(19)17-7-9-21-11-12-22-10-8-18-14(20)24-16(4,5)6/h7-12H2,1-6H3,(H,17,19)(H,18,20)

SMILES

CC(C)(C)OC(=O)NCCOCCOCCNC(=O)OC(C)(C)C

Boc-NH-PEG2-NH-Boc is a PEG-based, bis-protected linker designed to support the modular assembly of PROTACs through orthogonal amide-forming chemistry. Its protected termini enable controlled coupling to ligands while minimizing premature reactions, and the flexible ether-rich backbone can help tune linker length and conformational behavior in targeted protein degradation constructs. Detailed structural and reactivity considerations are provided below for experimental planning.

Structure: This molecule contains a short poly(ethylene glycol) ether segment providing hydrophilicity and conformational flexibility, flanked by two carbamate (Boc-protected) amine functionalities. The structure features ether linkages within the PEG region and carbamate carbonyls, with stable covalent bonds suitable for stepwise PROTAC synthesis.

Reactivity: Boc-protected amines are typically deprotected under mild acid conditions to reveal primary amines, which then participate in amide bond formation with activated carboxylic acids or activated esters. Coupling commonly follows established peptide-coupling principles using appropriate coupling reagents and base in compatible solvents. The linker’s flexible PEG segment generally supports efficient conjugation while preserving functional group compatibility during sequential PROTAC assembly.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂