Bromo-PEG3-alcohol
CAS No.: 57641-67-5
Cat No.: BP-501194
Purity: ≥95%
4.5 
Bromo-PEG3-alcohol is a functionalized poly(ethylene glycol) linker fragment featuring a terminal bromo group and a terminal hydroxyl group, providing a short, flexible PEG chain that can be incorporated into PROTAC architectures. The ether-rich PEG segment improves solubility and conformational mobility, helping the assembled degrader maintain productive geometry between a ligand that recruits an E3 ubiquitin ligase and a ligand that binds the target protein. In PROTAC design, the terminal bromo functionality serves as a reactive handle for chemoselective conjugation, enabling attachment to nucleophilic groups on other PROTAC components or to intermediate building blocks used during linker synthesis. The terminal alcohol can be further derivatized (e.g., to activated esters or ethers) to support controlled coupling strategies. This linker is valuable for researchers optimizing linker length, flexibility, and physicochemical properties to enhance ternary complex formation and targeted ubiquitination, thereby supporting systematic structure–activity studies in targeted protein degradation experiments.
Structure of 57641-67-5
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Bromo-PEG3-alcohol is a PEG-based PROTAC linker building block designed to provide a flexible, hydrophilic spacer for connecting a ligand-binding warhead to an E3 ligase recruiter. Its ether-rich backbone supports solubility and conformational adaptability, which can improve productive ternary-complex formation in targeted protein degradation workflows. The following sections describe its structure and practical reactivity considerations for PROTAC assembly in detail below.
Structure: Bromo-PEG3-alcohol contains a terminal bromo group and a terminal alcohol connected through an ethylene glycol repeat chain. The linker features ether linkages and an alkyl bromide, enabling stable covalent attachment strategies while maintaining high polarity and water compatibility.
Reactivity: The bromomethyl terminus is suitable for nucleophilic substitution reactions with ligand-derived nucleophiles such as amines, thiols, or oxygen nucleophiles under standard alkylation conditions. Typical approaches use polar aprotic solvents and base/acid–base control to promote nucleophile formation and minimize side reactions. The alcohol terminus can be functionalized via standard esterification or etherification chemistry to enable further coupling steps during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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