Bromoacetamido-PEG8-acid
CAS No.: 1698019-89-4
Cat No.: BP-501600
Purity: >95%
4.5 
Bromoacetamido-PEG8-acid is a polyethylene glycol linker bearing a terminal bromoacetamide electrophile and a carboxylic acid for convenient chemical handling. Structurally, it comprises an extended PEG chain (eight ethylene glycol units) that provides aqueous solubility and conformational spacing, while the bromoacetamide group enables selective covalent conjugation to nucleophilic residues such as cysteine thiols or primary amines under appropriate conditions. In PROTAC and targeted degradation designs, this linker functions as a modular spacer that connects two functional components—typically a ligand for an E3 ubiquitin ligase and a ligand for the target protein—by first installing the linker onto one partner through the reactive bromoacetamide handle and then using the terminal acid for subsequent coupling to the second component. The PEG8 length helps reduce steric interference at the ternary complex interface and can improve overall degradation efficiency by maintaining productive geometry and minimizing nonspecific interactions.
Structure of 1698019-89-4
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Bromoacetamido-PEG8-acid is a polyethylene glycol-based bifunctional linker designed for modular construction of PROTACs, enabling efficient conjugation between a ligand and an E3-recruiting element while maintaining favorable solubility and conformational flexibility. Its reactive bromoacetamide handle supports targeted formation of stable linkages, which can improve synthetic accessibility and facilitate systematic structure–activity studies. The following sections describe its structure and the practical reactivity considerations for PROTAC assembly in detail below.
Structure: The molecule contains a PEG chain terminating in a carboxylic acid and a bromoacetamide electrophile. It features ether linkages within the PEG segment, an amide linkage at the bromoacetamide terminus, and a reactive carbon–bromine bond suitable for nucleophilic substitution, yielding a stable conjugation point.
Reactivity: The bromoacetamide group is suited to nucleophilic substitution with amines or other nucleophiles under conditions commonly used for alkylation, typically in polar organic solvents or aqueous/organic mixtures. Reaction proceeds via formation of a covalent bond through displacement of bromide, with the amide carbonyl providing an electrophile activated for selective conjugation. Base selection and pH control are often used to balance nucleophile availability and minimize side reactions during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
