Azido-PEG8-CH2COOH
CAS No.: 1343472-07-0
Cat No.: BP-501297
Purity: ≥95%
4.5 
Azido-PEG8-CH2COOH is a polyethylene glycol linker terminated with an azide group and a carboxymethyl (–CH2COOH) functionality, providing a flexible, hydrophilic spacer suitable for PROTAC assembly. The PEG chain length and ether-rich backbone help reduce steric interference and improve solubility, while the terminal azide enables bioorthogonal conjugation strategies (most commonly via copper-free azide–alkyne cycloaddition or related click chemistries) to connect the linker to complementary alkyne-bearing ligands or handles. The carboxylic acid at the opposite end offers a chemically addressable site for amide coupling or other covalent attachment to targeting moieties, facilitating the construction of bifunctional degraders with controlled geometry. In targeted protein degradation research, such linkers are widely used to tune effective distance and relative orientation between the recruiter and ligand-binding domains, supporting efficient formation of the ternary complex and enabling systematic structure–activity studies.
Structure of 1343472-07-0
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG8-CH2COOH is a polyethylene glycol-based PROTAC linker featuring a terminal azide handle for bioorthogonal conjugation and a carboxylic acid for controlled coupling to targeting ligands. Its flexible PEG scaffold improves solubility and can help tune linker length and conformational freedom in ternary complex formation. This product is well suited for constructing PROTACs via modular assembly; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG chain terminated by an azide group and a carboxylic acid-bearing methylene segment. It contains ether linkages typical of PEG, an aliphatic methylene spacer, and an azide functional group, combining hydrophilicity with a chemically orthogonal reactive site.
Reactivity: The azide enables copper-catalyzed azide–alkyne cycloaddition or related azide-based conjugation strategies under conditions compatible with sensitive biomolecules. The carboxylic acid can be activated for amide bond formation using standard coupling chemistries, typically in polar organic solvents with base and coupling reagents. Mechanistically, azide conjugation proceeds via cycloaddition, while carboxyl activation proceeds through formation of an activated ester or acyl intermediate followed by nucleophilic amide formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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