Name: COOH-PEG1-COOtBu
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propanoic acid

Synonyms

Acid-PEG1-t-butyl ester; Acid-PEG1-C2-Boc; 3-(3-(tert-butoxy)-3-oxopropoxy)propanoic acid; Propanoic acid, 3-(2-carboxyethoxy)-, 1-(1,1-dimethylethyl) ester; 3-(2-Carboxyethoxy)propanoic acid 1-tert-butyl ester; 3-{3-[(2-Methyl-2-propanyl)oxy]-3-oxopropoxy}propanoic acid; Propanoic acid, 3,3'-oxybis-, 1,1-dimethylethyl ester

Boiling Point

341.9±22.0°C (Predicted)

Density

1.101±0.06 g/cm3 (Predicted)

InChI Key

ZDYGOKORAHMWLC-UHFFFAOYSA-N

InChI

InChI=1S/C10H18O5/c1-10(2,3)15-9(13)5-7-14-6-4-8(11)12/h4-7H2,1-3H3,(H,11,12)

SMILES

CC(C)(C)OC(=O)CCOCCC(=O)O

COOH-PEG1-COOtBu is a polyethylene glycol-based bifunctional linker designed to support PROTAC assembly by connecting a ligand-bearing handle to a second coupling partner. Its PEG character promotes solubility and conformational flexibility, helping maintain productive geometry between the target-binding and E3-recruiting elements. The carboxylic acid and protected carboxylate functionality enable modular synthesis routes, which are commonly used to generate degraders. The

Structure: The linker contains an ethylene glycol repeat unit bearing two carboxyl-derived termini, one presented as a free carboxylic acid and the other as a tert-butyl ester. It features ether connectivity within the PEG segment and ester/acid functional groups suitable for orthogonal coupling strategies.

Reactivity: PROTAC construction typically uses the free carboxylic acid for amide or ester bond formation via carbodiimide-mediated activation, often with coupling additives to improve efficiency. The tert-butyl ester can be selectively deprotected under acid conditions to regenerate a second carboxyl group for subsequent conjugation. Solvent systems such as polar aprotic or alcohol-containing media are commonly employed, with reaction temperatures and times optimized to preserve sensitive ligands.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂