m-PEG21-acid
Cat No.: BP-501976
4.5 
m-PEG21-acid is a monomethoxy-terminated polyethylene glycol (PEG) linker acid designed for PROTAC and related targeted protein degradation architectures. Structurally, it comprises a PEG chain of moderate length terminated with a carboxylic acid, providing a hydrophilic, flexible spacer that can reduce steric interference between the ligand-binding modules while maintaining sufficient reach for productive ternary complex formation. In PROTAC constructs, the linker acid serves as a chemically addressable handle for amide coupling or other conjugation strategies to attach the PEG spacer to targeting ligands and/or E3 ligase-recruiting moieties, thereby positioning the two binding elements at an appropriate distance and orientation. Its PEG character can also improve solubility and aqueous compatibility, which is often beneficial for synthesis, purification, and downstream biochemical evaluation of degradation potency.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG21-acid is a polyethylene glycol-based PROTAC linker designed to provide a flexible, hydrophilic spacer between a target-binding ligand and an E3 ligase-recruiting moiety. Its PEG architecture can help modulate effective intramolecular reach, reduce nonspecific hydrophobic interactions, and improve overall solubility in common linker–conjugation workflows. The carboxylic acid functionality enables robust, widely used coupling strategies for assembling PROTACs, and the detailed structural and synthetic considerations are described below.
Structure: m-PEG21-acid contains a linear PEG chain terminated by a carboxylic acid, offering an extended, conformationally flexible scaffold. The ether-rich backbone provides strong hydrogen-bonding capacity and high polarity, while the terminal carboxyl group enables formation of activated esters or amide bonds.
Reactivity: The carboxylic acid group is suitable for PROTAC assembly via standard carboxyl activation chemistries, such as carbodiimide-mediated coupling or conversion to reactive acid derivatives for amide formation. Typical conditions use polar aprotic solvents and base to promote activation, with coupling partners bearing amines or other nucleophiles. Reaction design generally follows established amide-bond formation mechanisms, minimizing hydrolysis and maintaining compatibility with sensitive ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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