DBCO-PEG12-acid
Cat No.: BP-501845
Purity: >95%
4.5 
DBCO-PEG12-acid is a heterobifunctional polyethylene glycol linker featuring a strained cyclooctyne (DBCO) for copper-free azide–alkyne cycloaddition and a terminal carboxylic acid for stable conjugation to amine- or hydrazide-bearing targeting ligands. The PEG12 chain provides a hydrophilic, flexible spacer that reduces steric interference and helps maintain productive proximity between the DBCO handle and an azide-functional partner, which is commonly introduced on a ligand or degrader module. In PROTAC and targeted protein degradation workflows, this linker enables modular assembly by “click” coupling under mild conditions, allowing researchers to generate well-defined conjugates with controlled linker length and improved solubility. Its carboxylate functionality further supports downstream attachment strategies for building multi-component degraders, facilitating systematic structure–activity studies and optimization of ternary-complex formation.
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* For research and manufacturing use only. Not for human or clinical use.
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This DBCO-PEG12-acid linker is designed for efficient conjugation in PROTAC workflows that benefit from bioorthogonal click chemistry. Its DBCO handle enables selective reaction with azide-bearing ligands, while the PEG-based spacer provides a flexible, water-compatible linkage that can improve effective engagement between targeting and recruiting modules. The acid functionality supports straightforward coupling strategies to install the linker onto PROTAC scaffolds. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a dibenzocyclooctyne (DBCO) moiety connected through a poly(ethylene glycol) spacer to a terminal carboxylic acid. It contains aromatic rings, an alkene-rich cyclooctyne core for click reactivity, and ether linkages within the PEG chain, yielding a hydrophilic, flexible conjugation platform.
Reactivity: DBCO-PEG-acid is commonly used in strain-promoted azide–alkyne cycloaddition (SPAAC) with azide-functional partners under catalyst-free conditions. Conjugation is typically performed in aqueous or mixed aqueous/organic solvents compatible with PEG linkers, where the terminal acid can be activated for amide or ester-forming coupling to PROTAC components. Reaction efficiency is influenced by pH, solvent composition, and azide accessibility; no copper catalyst is required for the SPAAC step.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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