Dimethylamino-PEG3
CAS No.: 2741-30-2
Cat No.: BP-501560
4.5 
Dimethylamino-PEG3 is a short, functionalized polyethylene glycol linker featuring a terminal dimethylamino group and an ether-based PEG chain of three repeating units. Structurally, it provides a flexible, hydrophilic spacer that can be used to separate a targeting ligand from an E3 ligase–recruiting module, helping to reduce steric interference and improve productive ternary complex formation in PROTACs. The dimethylamino terminus serves as a versatile attachment handle for linker conjugation strategies, enabling formation of amide, carbamate, or related linkages depending on the coupling chemistry used in the final PROTAC assembly. In targeted protein degradation research, such PEG spacers are widely employed to tune solubility, conformational freedom, and effective distance between binding elements, which can materially influence degradation potency and selectivity. This product is therefore a practical building block for constructing next-generation PROTAC linkers and for systematic structure–activity optimization in experimental workflows.
Structure of 2741-30-2
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Dimethylamino-PEG3 is a PEG-based PROTAC linker designed to provide a flexible, water-compatible connection between a ligand for an E3 ligase and a target-binding moiety. Its ether-rich backbone and tertiary amine functionality provide favorable solubility and conformational adaptability for linker derivatization workflows. The structure and reactivity considerations for constructing PROTACs with this linker are described in detail below.
Structure: The linker comprises a short poly(ethylene glycol) chain containing repeating ether linkages, terminated with a dimethylamino group. It features ether oxygen atoms that confer polarity and hydrogen-bond acceptor character, alongside a tertiary amine that can be protonated under mildly acidic conditions. Overall, it is flexible and hydrophilic.
Reactivity: The dimethylamino group is a tertiary amine and therefore does not provide an N–H for standard amide or carbamate formation. The terminal hydroxyl group is the principal derivatization handle and can be activated or converted to a suitable leaving group before coupling to a partner nucleophile. The tertiary amine can be protonated to tune charge and solubility, with reaction conditions selected to preserve the PEG chain.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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