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DP-C-4

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DP-C-4 is a dual PROTAC based on Cereblon for simultaneous degradation of EGFR and PARP.

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Molecular Formula

C72H78ClF2N15O14

Molecular Weight

1450.93

DP-C-4

- Specification
  - Related CAS
    
    2661609-36-3 (1S-isomer)
    
    Purity
    
    ≥98%
    
    Solubility
    
    Soluble in DMSO
    
    Appearance
    
    Yellow Solid
    
    Storage
    
    Store at -80°C, stored under nitrogen
    
    IUPAC Name
    
    6-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-N-[3-[[1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]triazol-4-yl]methoxy]-1-[[6-[4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]-6-oxohexyl]amino]-1-oxopropan-2-yl]hexanamide
    
    Synonyms
    
    6-({4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-N-(3-[(1-{2-[2-(2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-1-{[6-(4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzoyl}-1-piperazinyl)-6-oxohexyl]amino}-1-oxo-2-propanyl)hexanamide
- Properties
  - Density
    
    1.46±0.1 g/cm3
    
    InChI Key
    
    RXJUEWUXCCBXOG-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C72H78ClF2N15O14/c1-100-60-39-56-51(66(79-43-78-56)80-45-18-20-54(75)52(73)37-45)38-61(60)104-30-9-3-4-15-62(91)81-58(42-103-41-46-40-89(86-83-46)29-32-102-34-33-101-31-24-76-55-14-10-13-49-65(55)72(99)90(71(49)98)59-21-22-63(92)82-69(59)96)68(95)77-23-8-2-5-16-64(93)87-25-27-88(28-26-87)70(97)50-35-44(17-19-53(50)74)36-57-47-11-6-7-12-48(47)67(94)85-84-57/h6-7,10-14,17-20,35,37-40,43,58-59,76H,2-5,8-9,15-16,21-34,36,41-42H2,1H3,(H,77,95)(H,81,91)(H,85,94)(H,78,79,80)(H,82,92,96)
    
    Canonical SMILES
    
    COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCCCC(=O)NC(COCC4=CN(N=N4)CCOCCOCCNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C(=O)NCCCCCC(=O)N8CCN(CC8)C(=O)C9=C(C=CC(=C9)CC1=NNC(=O)C2=CC=CC=C21)F

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It is commonly abbreviated as: C₁V₁ = C₂V₂

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