Name: Fmoc-NMe-PEG3-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO

Appearance

Solid

ShelfLife

-20°C 3 years powder; -80°C 2 years in solvent

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

3-[2-[2-[2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Fmoc-N-methyl-N-amido-PEG3-acid; Fmoc-N-methyl-PEG3-CH2CH2COOH; Fmoc-NMe-PEG(3)-COOH; Fmoc-N-methyl-N-amido-PEG3-COOH; 5,8,11-Trioxa-2-azatetradecanedioic acid, 2-methyl-, 1-(9H-fluoren-9-ylmethyl) ester; 1-(9H-Fluoren-9-yl)-4-methyl-3-oxo-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid; 2,7,10,13-Tetraoxa-4-azahexadecan-16-oic acid, 1-(9H-fluoren-9-yl)-4-methyl-3-oxo-

Boiling Point

630.5±55.0°C (Predicted)

Density

1.218±0.06 g/cm3 (Predicted)

InChI Key

JKEBDIJQSKVIID-UHFFFAOYSA-N

InChI

InChI=1S/C25H31NO7/c1-26(11-13-31-15-17-32-16-14-30-12-10-24(27)28)25(29)33-18-23-21-8-4-2-6-19(21)20-7-3-5-9-22(20)23/h2-9,23H,10-18H2,1H3,(H,27,28)

SMILES

CN(CCOCCOCCOCCC(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

This Fmoc-NMe-PEG3-acid linker is designed for constructing PROTACs where controlled linker flexibility and solubility are advantageous for productive ternary complex formation. The Fmoc-protected amine functionality supports stepwise assembly, while the terminal carboxylic acid enables robust conjugation to targeting ligands or warheads. Its PEG-based spacer can reduce steric constraints and improve handling during synthesis. The detailed structure and reactivity considerations are provided below.

Structure: The molecule contains an Fmoc-protected N-methylated amine linked to a short poly(ethylene glycol) spacer terminating in a carboxylic acid. It features aromatic carbamate motifs, ether linkages within the PEG chain, and a terminal carboxyl group capable of forming amides or activated esters.

Reactivity: The carboxylic acid can be converted to amide-forming derivatives using standard coupling chemistries under mild base conditions, typically in polar aprotic solvents. The Fmoc group can be removed with base to reveal the amine for subsequent coupling. Coupling proceeds via activation of the acid followed by nucleophilic acyl substitution, commonly without requiring special catalysts beyond the coupling reagents.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂