Chloro-PEG2-Boc
CAS No.: 1442085-43-9
Cat No.: BP-501292
4.5 
Chloro-PEG2-Boc is a bifunctional PEG-based linker featuring a terminal alkyl chloride and a tert-butyl ester-protected carboxylic acid for subsequent derivatization. The short ethylene glycol chain provides aqueous solubility and conformational flexibility while maintaining a defined distance between conjugation sites, which is important for tuning the geometry of PROTAC assemblies. In PROTAC design, the chloro functionality enables nucleophilic substitution with amine- or thiol-bearing partners, allowing efficient attachment to warhead or E3-ligase–binding moieties; the tert-butyl ester protects the carboxylic acid during multi-step synthesis and can be removed to reveal the acid for further coupling. This linker is valuable for constructing modular conjugates where minimizing steric interference and optimizing linker length are critical for productive ternary complex formation and targeted protein degradation performance.
Structure of 1442085-43-9
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Chloro-PEG2-Boc is a PEG-based linker designed to connect ligands in targeted protein degradation (PROTAC) constructs while providing a flexible hydrophilic spacer that can improve effective spatial presentation of the two binding elements. Its chloro handle enables synthetic elaboration, and the tert-butyl ester-protected carboxyl functionality supports controlled downstream coupling strategies. The combination of PEG flexibility and orthogonal protection makes it well suited for building PROTACs through modular, stepwise assembly; detailed structural and reactivity guidance is provided below.
Structure: Chloro-PEG2-Boc contains a short poly(ethylene glycol) segment providing hydrophilicity and conformational flexibility, together with a chloro leaving group for substitution chemistry. A tert-butyl ester-protected carboxylic acid is present, contributing to chemical stability under mild conditions and enabling deprotection when required.
Reactivity: The chloro substituent is suitable for nucleophilic substitution reactions commonly used to install PROTAC coupling partners, following principles of SN-type displacement under appropriate base and solvent systems. The tert-butyl ester is typically removed under acidic conditions to reveal the carboxylic acid for subsequent amide-forming coupling. Selection of solvent, temperature, and base should be guided by the nucleophile’s reactivity and the stability of the ligand moieties.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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