m-PEG4-COOH
CAS No.: 67319-28-2
Cat No.: BP-501003
Purity: ≥95%
4.5 
m-PEG4-COOH is a methoxy-terminated, meta-substituted polyethylene glycol linker bearing a terminal carboxylic acid, providing a defined, flexible hydrophilic chain length suitable for PROTAC and targeted protein degradation constructs. Structurally, the PEG segment acts as a spacer that can reduce steric interference between the two binding modules (typically an E3 ligase ligand and a target-binding moiety), while the carboxyl group enables robust conjugation via standard amide coupling or related carboxyl-reactive chemistries. In PROTAC design, this linker supports controlled spatial presentation of each ligand to promote productive ternary complex formation and can improve solubility and handling of large conjugates. As a modular building block, m-PEG4-COOH is valuable for systematically tuning linker length and polarity, facilitating experimental optimization of degradation potency, selectivity, and physicochemical properties in targeted degradation research.
Structure of 67319-28-2
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This m-PEG4-COOH linker is a polyethylene glycol-based carboxylic acid functionality designed to provide solubility, conformational flexibility, and a reliable handle for PROTAC assembly. Its PEG spacer can help tune linker length and reduce nonspecific interactions, supporting efficient formation of productive ternary complexes. The detailed structural and reactivity characteristics are described below to guide researchers in appropriate conjugation strategies for targeted protein degradation workflows.
Structure: The linker comprises an m-PEG ethylene glycol segment terminated with a carboxylic acid, featuring ether linkages that confer hydrophilicity and chain flexibility. The terminal carboxyl group enables formation of amide or ester derivatives, while the PEG backbone promotes aqueous compatibility and minimizes aggregation.
Reactivity: The carboxylic acid can be activated for amide bond formation using standard coupling chemistries such as carbodiimide-based systems with an auxiliary nucleophile, or via activated ester intermediates. Reactions are typically performed under inert or controlled conditions with polar aprotic solvents, maintaining conditions compatible with sensitive ligands. Coupling proceeds through carboxyl activation followed by nucleophilic acyl substitution to install the linker onto PROTAC targeting modules.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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