Hydroxy-PEG4-t-butyl ester

 CAS No.: 518044-32-1  Cat No.: BP-500169  Purity: ≥95% 4.5  

Hydroxy-PEG4-t-butyl ester is a protected PEG linker intermediate used in ADC synthesis. The t-butyl group protects the acid functionality, enabling selective conjugation steps while the PEG4 spacer enhances biocompatibility and payload solubility.

Hydroxy-PEG4-t-butyl ester

Structure of 518044-32-1

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Category
PROTAC Linker
Molecular Formula
C15H30O7
Molecular Weight
322.39
Appearance
Colorless to light yellow to light orange clear liquid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DCM, DMSO, Water
Appearance
Colorless to light yellow to light orange clear liquid
Storage
Store at 2-8°C
Shipping
Room temperature, or blue ice upon request.
IUPACName
tert-butyl 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate
Synonyms
HO-PEG4-CH2CH2COOtBu; Hydroxy-PEG4-(CH2)2-Boc; OH-PEG4-TBA; OH-PEG4-CH2CH2COOtBu; HO-PEG4-t-butyl ester; tert-Butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate; 15-Hydroxy-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester; 2-Methyl-2-propanyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-hydroxy-, 1,1-dimethylethyl ester
Boiling Point
406.8±35.0 °C at 760 mmHg
Density
1.047±0.1 g/cm3
InChI Key
FJRDXEGYAVAMLB-UHFFFAOYSA-N
InChI
InChI=1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
Canonical SMILES
CC(C)(C)OC(=O)CCOCCOCCOCCOCCO
Biological Activity
Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-<br/>(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 191). In Vitro: ADCs are comprised of an antibody to which is<br/>attached an ADC cytotoxin through an ADC linker.

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L

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: t-Boc-N-amido-PEG4-azide | m-PEG24-Br | N-Mal-N-bis(PEG2-NHS ester) | m-PEG2-Tos | endo-BCN-PEG4-Boc | SPDP-PEG7-acid | FmocNH-PEG3-CH2CH2NH2 | Bromo-PEG3-bromide | Bis-MAL-PEG4-PEG12-Lysine-Tris(PEG24-COOH) | Azido-PEG5-S-methyl ethanethioate | Hydroxy-PEG4-t-butyl ester

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