m-PEG3-AcS

m-PEG3-AcS is a polyethylene glycol-based linker designed to support efficient conjugation strategies used in PROTAC assembly. Its PEG character improves solubility and can help maintain productive spatial relationships between ligand modules, which is important for targeted protein degradation workflows. The acyl-sulfide functionality enables practical coupling to generate stable PROTAC architectures.

Structure: The linker is a PEG-derived chain bearing an acyl-sulfide motif, providing an ether-rich, flexible scaffold. It contains ether linkages along the PEG segment and a sulfur-containing thioester-like functionality, with a polar, hydrogen-bond-accepting environment that supports aqueous compatibility and conformational mobility.

Reactivity: m-PEG3-AcS is suitable for PROTAC linker construction where sulfide-containing intermediates are required. Conjugation is typically performed under controlled, anhydrous conditions to preserve the reactive sulfur functionality, using standard organic synthesis protocols for acyl-sulfide transformations. Mild base or nucleophilic activation may be used depending on the partner ligand, with polar aprotic solvents commonly employed to promote coupling and minimize side reactions.