m-PEG9-phosphonic acid ethyl ester
Cat No.: BP-501745
4.5 
m-PEG9-phosphonic acid ethyl ester is a mono-functional, methoxy-terminated PEG-based linker bearing a phosphonate protected as an ethyl ester. Structurally, it provides a flexible hydrophilic polyethylene glycol chain of moderate length while presenting a chemically addressable phosphonate handle at the terminus, enabling controlled conjugation to PROTAC components or other targeting ligands. In PROTAC design, PEG linkers are commonly used to tune the spatial relationship between the “warhead” moiety and the recruited E3 ligase ligand, improving productive ternary complex formation and reducing steric mismatch. The phosphonate group can serve as a versatile attachment point for subsequent derivatization (e.g., conversion to a free phosphonic acid or coupling to electrophilic partners), facilitating the assembly of degraders with defined linker chemistry. This product is valuable for researchers seeking reproducible linker architectures that balance solubility, conformational flexibility, and modular functional-group compatibility during targeted protein degradation workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG9-phosphonic acid ethyl ester is a polyethylene glycol-based PROTAC linker designed to provide conformational flexibility and improved solubility for targeted protein degradation constructs. The phosphonate ethyl ester functionality enables reliable downstream functionalization to connect ligands while maintaining a stable, linker-like environment between binding elements. Its ether-rich backbone provides a flexible, polar spacer for PROTAC and related conjugation workflows. The following sections describe the structure and reactivity considerations in detail.
Structure: The molecule contains a linear PEG chain featuring repeating ether units and a terminal diethyl phosphonate group connected through an alkyl/ether segment. It comprises C–O ether linkages and phosphonate P–O ester bonds, giving a polar, flexible linear scaffold.
Reactivity: Phosphonic acid ester groups are commonly used as protected handles for controlled conversion to phosphonic acids or for coupling strategies in linker assembly. Suitable transformations typically rely on ester hydrolysis under aqueous acidic or basic conditions, followed by activation for subsequent bond formation. Reaction planning should consider PEG stability, solvent compatibility (polar protic or mixed solvent systems), and mild conditions to preserve ether integrity and avoid PEG cleavage.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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