m-PEG36-amine
Cat No.: BP-501879
4.5 
m-PEG36-amine is a monomethoxy-terminated polyethylene glycol linker terminated with a primary amine, providing a flexible, hydrophilic chain suitable for bioconjugation. Structurally, the long PEG backbone acts as an extended spacer that reduces steric interference and improves aqueous solubility of PROTAC constructs, while the terminal amine enables straightforward coupling to activated carboxylic acid groups or other electrophiles to form stable amide or related linkages. In targeted protein degradation design, this type of PEG linker can be used to tune the effective distance and relative orientation between a binding ligand (e.g., E3 ligase recruiter) and a target-binding moiety, thereby supporting productive formation of the ternary complex required for ubiquitination and subsequent degradation. Its value lies in enabling systematic linker optimization and improving handling and formulation of multicomponent degraders for experimental evaluation in biochemical and cellular assays.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG36-amine is a polyethylene glycol (PEG)-based amine linker designed to connect targeting ligands in PROTAC architectures while improving solubility, flexibility, and effective spatial presentation of the two binding elements. Its ether-rich, hydrophilic backbone can reduce nonspecific aggregation and support productive ternary complex formation. The sections below describe key structural features and practical considerations for using this linker in targeted protein degradation constructs.
Structure: The linker consists of a PEG repeating-unit chain terminated with a primary amine. It contains multiple ether linkages along the backbone, providing high polarity and conformational flexibility. The terminal amine offers a reactive handle for forming stable covalent bonds to complementary functional groups under standard organic coupling conditions.
Reactivity: The primary amine enables formation of amide, urea, or related linkages through nucleophilic acyl substitution with activated carboxylic acids (e.g., NHS esters or acid chlorides) or through carbodiimide-mediated coupling. For PROTAC assembly, typical strategies include reacting the amine with electrophilic partners under mildly basic conditions in polar aprotic solvents, followed by purification to remove small-molecule reagents and byproducts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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