m-PEG48-Br
Cat No.: BP-502049
4.5 
m-PEG48-Br is a monofunctional, bromo-terminated polyethylene glycol linker featuring an extended PEG chain that provides strong aqueous solubility and conformational flexibility. The bromo group serves as a reactive handle for subsequent chemoselective conjugation, enabling attachment to PROTAC scaffolds or to other functional modules such as ligands, targeting moieties, or solubilizing fragments through standard nucleophilic substitution or related coupling strategies. In targeted protein degradation designs, PEG linkers are widely used to tune the effective distance and relative orientation between the two binding elements of a PROTAC, helping to reduce steric interference and improve productive formation of the ternary complex with the E3 ligase and the target protein. This reagent is valuable for constructing next-generation degradation constructs where linker length and hydrophilicity are critical parameters for potency, stability, and experimental tractability in biochemical and cell-based assays.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG48-Br is a bromine-terminated polyethylene glycol linker designed to support modular PROTAC assembly through reliable electrophilic functionalization. Its PEG-based, ether-rich scaffold provides conformational flexibility and aqueous compatibility, helping to position recruited ligands for productive ternary complex formation. In PROTAC workflows, this linker serves as a versatile intermediate that can be converted into reactive coupling handles, enabling efficient synthesis of targeted protein degraders; detailed structural and reactivity considerations are provided below.
Structure: The linker is built from a polyethylene glycol chain terminated with a bromine atom. It contains repeating ether linkages that confer polarity and strong solvation, while the terminal C–Br bond provides a clear electrophilic site for subsequent derivatization. The overall structure is flexible and typically water-compatible.
Reactivity: Bromine termination enables nucleophilic substitution and related haloalkyl coupling strategies under standard organic synthesis conditions. Suitable nucleophiles include thiols, amines, and other anionic species, with base-mediated generation of the nucleophile often improving conversion. Common solvents include polar aprotic media, and reaction temperature is selected to balance substitution efficiency with preservation of sensitive functional groups. For PROTAC synthesis, this handle supports stepwise attachment of ligand warheads and E3-recruiting motifs.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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