TCO-PEG4-NHS ester

 CAS No.: 1613439-69-2  Cat No.: BP-500134  Purity: >99.5% 4.5  

TCO-PEG4-NHS ester enables rapid click chemistry conjugation through its TCO group and amine-reactive NHS ester. It is widely used as an ADC linker in pretargeted drug delivery strategies.

TCO-PEG4-NHS ester

Structure of 1613439-69-2

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Category
PROTAC Linker
Molecular Formula
C24H38N2O10
Molecular Weight
514.57
Appearance
Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
>99.5%
Solubility
10 mm in DMSO
Appearance
Solid
ShelfLife
0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage
-20°C
Shipping
-20°C (International: -20°C)
IUPACName
Synonyms
TCO PEG4 succinimidyl ester; 2,5-dioxopyrrolidin-1-yl (E)-1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
Density
1.2±0.1 g/cm3
InChI Key
ZKPMRASGLDBKPF-OWOJBTEDSA-N
InChI
InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1+
Canonical SMILES
C1CC=CCCC(C1)OC(=O)NCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
Biological Activity
TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]
ConcentrationVolumeMass1 mg5 mg10 mg
1 mM1.9434 mL9.7169 mL19.4337 mL
5 mM0.3887 mL1.9434 mL3.8867 mL
10 mM0.1943 mL0.9717 mL1.9434 mL

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: DBCO-NHCO-C4-NHS ester | Propargyl-PEG2-N-bis(PEG2) | t-Boc-N-amido-PEG2-NHS ester | Propargyl-PEG12-methane | 14,14,14-Trifluoro-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate | m-PEG13-Hydrazide | m-PEG3-aldehyde | Azido-PEG5-PFP ester | DBCO-NHCO-PEG2-maleimide | m-PEG6-Tos | TCO-PEG4-NHS ester

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