Mal-amido-PEG24-acid
Cat No.: BP-501935
4.5 
Mal-amido-PEG24-acid is a heterobifunctional polyethylene glycol (PEG) linker bearing a maleimide group for thiol-selective conjugation and a terminal carboxylic acid for subsequent coupling or attachment to PROTAC scaffolds. Structurally, it consists of a long, flexible PEG chain that provides aqueous solubility and spatial reach, while the maleimide enables efficient formation of stable thioether bonds with cysteine-containing ligands or engineered thiol handles on binding moieties. In PROTAC design, this linker helps position the two functional components—typically a target-binding ligand and an E3 ligase recruiter—by reducing steric constraints and promoting productive ternary-complex formation. The carboxylic acid handle supports amide coupling to linker arms or synthesis of conjugates that require a defined attachment point. As a modular PEG linker, it is valuable for systematic optimization of linker length, flexibility, and conjugation chemistry in targeted protein degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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Mal-amido-PEG24-acid is a polyethylene glycol (PEG)-based PROTAC linker designed to connect a maleimide-reactive handle to a carboxylic acid functional group, enabling modular assembly of targeted protein degraders. Its flexible, hydrophilic spacer can improve solubility and support productive ternary complex formation by reducing steric constraints between the ligand and the recruited E3 ligase moieties. The detailed structural and synthetic considerations are provided below.
Structure: The linker contains a PEG chain providing a flexible, hydrophilic backbone, an amide linkage connecting the PEG to a maleimide-derived functionality, and a terminal carboxylic acid for downstream coupling. It features stable covalent amide and ether linkages alongside a maleimide moiety suitable for selective conjugation.
Reactivity: The maleimide functionality is typically used for chemoselective thiol–maleimide conjugation under mildly basic aqueous conditions, following established maleimide reactivity principles. For PROTAC construction, the carboxylic acid end can be activated for amide bond formation with amine-bearing ligands using standard coupling chemistries. Commonly used solvents include aqueous buffers with compatible organic cosolvents, and reactions are generally performed under conditions that preserve maleimide integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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