HS-PEG10-CH2CH2COOH
Cat No.: BP-501997
4.5 
HS-PEG10-CH2CH2COOH is a thiol-terminated, carboxylic acid–functionalized polyethylene glycol linker designed for modular PROTAC and targeted protein degradation workflows. Structurally, it consists of an oligo(ethylene glycol) chain of approximately ten ethylene oxide units that provides a flexible, hydrophilic spacer between two reactive termini, with a terminal thiol (for conjugation to thiol-reactive handles or via thiol–maleimide chemistry) and a terminal carboxylic acid for further coupling to amine- or activated-ester–bearing ligands. In PROTAC assemblies, such PEG linkers help tune effective molarity, reduce steric interference between the recruiting ligand and the E3 ligase binder, and improve aqueous solubility, which can enhance synthesis robustness and facilitate biological testing. This linker is valuable for researchers seeking reproducible, chemically well-defined conjugation strategies when optimizing linker length and polarity to achieve efficient ternary complex formation and degradation potency.
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* For research and manufacturing use only. Not for human or clinical use.
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HS-PEG10-CH2CH2COOH is a PEG-based bifunctional linker designed for constructing PROTACs and related targeted protein degradation conjugates. Its flexible ethylene glycol segment helps tune linker length and conformational freedom, while the terminal thiol and carboxylic acid enable versatile coupling strategies to assemble E3 ligase recruiters and target-binding ligands. The combination of solubility-enhancing PEG character and orthogonal functional groups supports efficient synthesis and subsequent bioconjugation workflows; the detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a poly(ethylene glycol) chain terminating in a thiol and a carboxylic acid, with an intervening ethylene spacer to connect the PEG segment to the alkyl acid. It contains ether linkages along the PEG backbone, an aliphatic thioether-forming functionality at the terminus, and a carboxylic acid for salt formation or activation.
Reactivity: The carboxylic acid is typically converted to an activated ester or amide-forming intermediate using standard coupling chemistries, enabling reaction with primary amines under mild base conditions. The terminal thiol can participate in thiol–maleimide conjugation or disulfide exchange strategies, depending on the electrophile used. Commonly employed solvents include polar aprotic media and aqueous buffers compatible with PEG linkers, with inert atmosphere recommended to minimize thiol oxidation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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