Mal-PEG6-Mal
Cat No.: BP-502070
Purity: ≥95%
4.5 
Mal-PEG6-Mal is a bifunctional polyethylene glycol linker bearing two maleimide termini, providing a flexible, water-soluble spacer of moderate length suitable for thiol–maleimide conjugation chemistry. The maleimide groups react selectively with sulfhydryl-containing partners to form stable thioether linkages, enabling researchers to connect two biomolecular or small-molecule components while minimizing steric interference and maintaining favorable aqueous compatibility. In PROTAC and targeted protein degradation workflows, this type of linker is commonly used to bridge a ligand or warhead equipped with a thiol (or introduced via cysteine engineering or reducing steps) to another thiol-functionalized module, thereby positioning the two binding elements for productive ternary complex formation with the target protein and the E3 ligase. Its PEG-based architecture can improve solubility and reduce nonspecific aggregation, facilitating systematic structure–activity relationship studies and optimization of degradation potency and cooperativity.
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* For research and manufacturing use only. Not for human or clinical use.
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Mal-PEG6-Mal is a bifunctional, PEG-based linker designed for efficient conjugation in targeted protein degradation workflows. Its two maleimide termini enable robust, chemoselective attachment to thiol-bearing ligands, supporting the assembly of PROTACs with controlled spacing and improved aqueous compatibility. Researchers can leverage this linker to build degraders that maintain productive geometry for ternary complex formation; the detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a flexible polyethylene glycol backbone terminated by two maleimide groups. It contains conjugated maleimide alkenes capable of undergoing thiol addition, and an ether-rich PEG segment that enhances solubility and conformational mobility. Overall, it behaves as a stable, bifunctional electrophile for selective conjugation.
Reactivity: Maleimides react with free thiols via a Michael-type addition, forming stable thioether linkages under mildly basic to neutral conditions. For PROTAC construction, thiol-functionalized warheads or binding ligands are typically reacted with the linker in aqueous or mixed aqueous solvents, with careful control of competing nucleophiles and thiol oxidation. Common practice uses freshly prepared thiols and inert handling to preserve reactivity; no special catalysts are generally required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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