Fmoc-NH-PEG2-NHS ester
CAS No.: 1807534-85-5
Cat No.: BP-500349
Purity: ≥95%
4.5 
Fmoc-NH-PEG2-NHS ester is an amine-reactive PEG-based linker designed for constructing PROTAC and related targeted degradation conjugates. Structurally, it combines an Fmoc-protected amine handle with a short, two–ethylene glycol unit PEG spacer and an NHS ester functional group, enabling efficient coupling to primary amines on ligands such as lysine-bearing peptides, engineered protein-binding modules, or amino-functionalized targeting moieties. In PROTAC workflows, the NHS ester provides a stable yet synthetically tractable route to form amide bonds, while the PEG segment imparts conformational flexibility and improved solubility, often helping to preserve productive ternary-complex formation by reducing steric constraints between the binding elements. The Fmoc group further supports stepwise, orthogonal assembly strategies in linker synthesis. This reagent is valuable for researchers seeking modular, reproducible linker installation and tunable spacing in targeted protein degradation studies.
Structure of 1807534-85-5
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Fmoc-NH-PEG2-NHS ester, combines an orthogonally protected amine with a short polyethylene glycol spacer and an NHS-activated ester for efficient bioconjugation. Its design supports modular assembly of bifunctional degraders by enabling stable amide formation with primary amines on targeting ligands while preserving linker flexibility and reducing steric constraints. The detailed Structure and Reactivity considerations are provided below for experimental planning.
Structure: The molecule contains an Fmoc-protected nitrogen attached to a short PEG chain terminating in an N-hydroxysuccinimide ester. It features an aromatic carbamate (Fmoc), ether linkages within the PEG segment, and an activated carboxylate ester suitable for nucleophilic acyl substitution. Overall, it is a polar, water-compatible linker.
Reactivity: The NHS ester reacts with primary amines to form stable amide bonds via nucleophilic acyl substitution, typically under mildly basic aqueous or mixed solvent conditions. For PROTAC construction, the activated ester is paired with amine-bearing ligands, with careful control of pH and stoichiometry to limit hydrolysis. Common solvents include water, buffered aqueous media, and compatible alcohol/water mixtures; catalysts are generally not required, but temperature and reaction time should be optimized.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
