Name: Mal-PEG8-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Light Yellow or White Solid

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Mal-PEG8-CH2CH2COOH; Maleimide-PEG8-CH2CH2COOH; Mal-PEG8-COOH; Mal-PEG8-propionic acid; 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid; 4,7,10,13,16,19,22,25-Octaoxaheptacosanoic acid, 27-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-; 3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-

Boiling Point

634.6±55.0°C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

KLZPPWOSICDUKQ-UHFFFAOYSA-N

InChI

InChI=1S/C23H39NO12/c25-21-1-2-22(26)24(21)4-6-30-8-10-32-12-14-34-16-18-36-20-19-35-17-15-33-13-11-31-9-7-29-5-3-23(27)28/h1-2H,3-20H2,(H,27,28)

SMILES

C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	1.9173 mL	9.5866 mL	19.1732 mL
5 mM	0.3835 mL	1.9173 mL	3.8346 mL
10 mM	0.1917 mL	0.9587 mL	1.9173 mL

Mal-PEG8-acid is a PEG-based PROTAC linker featuring a maleimide handle and a terminal carboxylic acid, enabling efficient conjugation strategies used to assemble targeted protein degraders. Its flexible ethylene glycol segment improves solubility and spatial reach between binding modules, while the maleimide moiety supports selective coupling to thiol-bearing ligands. The terminal acid facilitates downstream functionalization and controlled attachment to other PROTAC components. Detailed structural and reactivity considerations are provided below.

Structure: Mal-PEG8-acid contains a maleimide electrophile connected to an extended poly(ethylene glycol) chain, terminating in a carboxylic acid. The molecule incorporates an alkene within the maleimide ring, ether linkages along the PEG backbone, and a polar acidic group, yielding a hydrophilic, conformationally flexible linker suited for PROTAC assembly.

Reactivity: The maleimide group undergoes thiol–maleimide Michael addition with cysteine or reduced thiol-containing ligands under mildly basic to neutral aqueous conditions, typically using fresh thiols to minimize side reactions. Coupling is commonly performed in buffered solvents compatible with maleimide stability, with careful control of pH and thiol stoichiometry. The carboxylic acid enables subsequent amide or ester-forming coupling to complementary PROTAC fragments using standard peptide-coupling chemistries.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂