Methylamino-PEG7-benzyl
Cat No.: BP-501869
Purity: >95%
4.5 
Methylamino-PEG7-benzyl is a polyethylene glycol–based PROTAC linker featuring a benzyl terminus and a terminal methylamino group, connected through a PEG7 chain that provides a flexible, hydrophilic spacer. Structurally, the PEG segment increases solubility and conformational freedom, helping the degrader components adopt productive geometries for ternary complex formation. In PROTAC design, this linker can be used to conjugate an E3 ligase-binding ligand and a target-binding moiety while minimizing steric clashes and reducing nonspecific hydrophobic interactions; the benzyl handle and the amine functionality enable straightforward synthetic attachment routes to the two binding partners. Its value for targeted protein degradation research lies in its ability to tune linker length and polarity, often improving cellular performance by balancing membrane compatibility with effective intracellular engagement of the degradation machinery.
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* For research and manufacturing use only. Not for human or clinical use.
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Methylamino-PEG7-benzyl is a PEG-based linker designed to support targeted protein degradation workflows by providing a flexible, hydrophilic spacer between a ligand and an E3-recruiting element. Its benzyl handle enables robust conjugation strategies, while the methylamino functionality supports controlled attachment chemistries commonly used in PROTAC assembly. The combination of ether-rich chain flexibility and reactive benzyl-derived functionality can help optimize overall linker length, solubility, and productive ternary complex formation; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a benzyl moiety connected to a polyethylene glycol chain and terminates with a methylamino group. It features ether linkages within the PEG segment, aromatic C–C bonding in the benzyl ring, and a primary amine-derived functionality. The PEG backbone provides high polarity and conformational flexibility, while the benzyl group offers a conjugation-ready aromatic handle.
Reactivity: PROTAC construction using this linker typically relies on amine- or benzyl-derived coupling logic, followed by purification of the resulting conjugates. Reaction design is commonly guided by chemoselective amide/urea formation from the methylamino group or benzyl-functional transformations that enable stable linkage to protein-binding ligands. Mild base or coupling reagents in polar organic solvents are often used to preserve labile functionalities, with reaction monitoring by chromatographic or spectrometric methods to ensure controlled conversion and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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