Name: mPEG6-thiol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>95%

Appearance

Colorless Liquid

Storage

4°C, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol

Synonyms

mPEG6-SH; 2,5,8,11,14,17-hexaoxanonadecane-19-thiol

InChI Key

FCNSUDTWFXNQBG-UHFFFAOYSA-N

InChI

InChI=1S/C13H28O6S/c1-14-2-3-15-4-5-16-6-7-17-8-9-18-10-11-19-12-13-20/h20H,2-13H2,1H3

SMILES

COCCOCCOCCOCCOCCOCCS

mPEG6-thiol is a methoxy PEG thiol linker used to introduce a flexible hydrophilic spacer and a thiol handle into PROTAC-related conjugates. Its longer PEG segment can enhance solvation and reduce steric congestion during staged assembly. Details are provided below.

Structure: The compound contains a methoxy-capped oligoethylene glycol backbone terminating in a thiol group. The ether-rich chain contributes polarity and conformational freedom, while the thiol provides nucleophilic sulfur reactivity.

Reactivity: The terminal thiol is suited to maleimide addition, haloacetamide alkylation, alkyl halide substitution, or disulfide exchange depending on the partner handle. Mild base or buffered systems are used to balance thiolate reactivity and functional-group stability. Low-oxidation handling helps prevent disulfide side products before PROTAC coupling.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂