N-Mal-N-bis(PEG2-acid)
CAS No.: 2110449-02-8
Cat No.: BP-501211
4.5 
N-Mal-N-bis(PEG2-acid) is a branched trifunctional polyethylene glycol–based PROTAC linker bearing two PEG2-carboxylic acid arms and one maleimide (Mal) handle, enabling selective conjugation to thiol-containing ligands. Structurally, it provides a hydrated, flexible spacer that helps tune the effective distance and relative orientation between the two binding elements of a degrader while reducing steric clashes and promoting productive ternary complex formation. In PROTAC design, the maleimide group reacts with cysteine or other thiol moieties on one component, generating a stable thioether linkage, after which the remaining PEG2-acid termini can be used for further coupling or for incorporation into a defined linker architecture. Its short, symmetric PEG character makes it particularly useful when researchers need compact yet water-soluble linkers to balance solubility, linker dynamics, and degradation efficiency in targeted protein degradation experiments.
Structure of 2110449-02-8
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N-Mal-N-bis(PEG2-acid) is a polyethylene glycol (PEG)-based PROTAC linker designed to connect ligand warheads while providing solubility, conformational flexibility, and a hydrophilic spacer that can support productive ternary complex formation. Its multifunctional architecture enables robust conjugation strategies commonly used in targeted protein degradation workflows. The structure and reactivity characteristics of this linker are described in detail below to guide experimental design and synthesis planning.
Structure: This linker contains a maleimide core for selective Michael-type reactivity and bis-PEG-acid arms that incorporate carboxylic acid functionality. The PEG segments provide hydrophilic, flexible ether linkages, while the maleimide ring offers an electrophilic alkene suitable for controlled conjugation under mild conditions.
Reactivity: The maleimide moiety is typically engaged via nucleophilic addition of thiols through a Michael-type mechanism, forming a stable thioether linkage. PROTAC assembly commonly uses thiol-bearing ligands or intermediate thiol handles, with reactions performed in aqueous or mixed aqueous buffers at near-neutral conditions to preserve maleimide reactivity. Carboxylic acid groups are suited for subsequent amide coupling using standard peptide-coupling reagents, often in the presence of activating agents and appropriate base/solvent systems.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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