MZP-55

 CAS No.: 2010159-48-3  Cat No.: BP-400043 4.5  

MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. MZP-55 binds to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. MZP-55 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC50s of 7.31 ± 0.03 and 6.57 ± 0.02, respectively.

MZP-55

Structure of 2010159-48-3

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PROTAC
Molecular Formula
C57H70ClN7O10S
Molecular Weight
1080.72

* For research and manufacturing use only. Not for human or clinical use.

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Solubility
Soluble in DMSO
Storage
Powder<br/>-20°C<br/>3 years<br/><br/><br/> <br/>4°C<br/>2 years<br/><br/><br/>In solvent<br/>-80°C<br/>6 months<br/><br/><br/> <br/>-20°C<br/>1 month
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Room temperature in continental US; may vary elsewhere
Synonyms
MZP-55; MZP 55; MZP55; (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[2-[[4-[(2S,4R)-1-acetyl-4-(4-chloroanilino)-2-methyl-3,4-dihydro-2H-quinolin-6-yl]benzoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
InChI Key
UHWNJFZTYJNBAN-HYXXSBGTSA-N
InChI
InChI=1S/C57H70ClN7O10S/c1-36-29-48(62-45-18-16-44(58)17-19-45)47-30-43(15-20-49(47)65(36)38(3)66)40-11-13-42(14-12-40)54(69)59-21-22-72-23-24-73-25-26-74-27-28-75-34-51(68)63-53(57(4,5)6)56(71)64-33-46(67)31-50(64)55(70)60-32-39-7-9-41(10-8-39)52-37(2)61-35-76-52/h7-20,30,35-36,46,48,50,53,62,67H,21-29,31-34H2,1-6H3,(H,59,69)(H,60,70)(H,63,68)/t36-,46+,48+,50-,53+/m0/s1
Canonical SMILES
CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)NCCOCCOCCOCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)NC7=CC=C(C=C7)Cl

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: Boc-C5-O-C5-O-C6-Cl | N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester | JH-XI-10-02 | BETd-246 | C-NH-Boc-C-Bis-(C1-PEG1-PFP) | (R)-CR8 | dAURK-4 | m-PEG4-CH2-aldehyde | PROTAC BRD9 Degrader-1 | dBET1 | MZP-55

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