N-(Azido-PEG3)-N-bis(PEG3-Boc)
CAS No.: 2055042-56-1
Cat No.: BP-501341
Purity: 97%
4.5 
N-(Azido-PEG3)-N-bis(PEG3-Boc) is a branched trifunctional polyethylene glycol linker reagent featuring one azide handle and two tert-butyl ester-protected carboxylic acid termini. Structurally, it comprises a short PEG3 chain architecture that provides aqueous solubility and conformational flexibility, while the two protected acid arms can be deprotected to reveal carboxylic acids for controlled functionalization. In PROTAC design, the azide group serves as a versatile attachment point for installing or exchanging targeting and E3-ligase–binding warheads via azide-compatible coupling strategies, whereas the PEG spacers help tune linker length and reduce steric interference at the ternary complex interface. This reagent is valuable for researchers seeking modular, reproducible linker synthesis routes, facilitating systematic evaluation of linker geometry and physicochemical properties that can strongly influence targeted protein degradation efficiency and selectivity in experimental PROTAC workflows.
Structure of 2055042-56-1
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
N-(Azido-PEG3)-N-bis(PEG3-Boc) is a versatile PEG-based PROTAC linker building block designed to introduce an azide handle for bioorthogonal conjugation while providing tert-butyl ester-protected carboxyl functionalities for controlled coupling. Its polyethylene glycol segments enhance solubility and reduce nonspecific interactions, supporting efficient formation of targeted protein degraders. The azide enables modular attachment to ligands or scaffolds, and the tert-butyl ester-protected carboxyl groups support stepwise synthesis. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises polyethylene glycol repeat units bearing an azide substituent and two tert-butyl ester-protected carboxylic acid functionalities. It contains ether linkages typical of PEG chains, an azide moiety for click chemistry, and tert-butyl ester groups that mask carboxylic acids during assembly. Overall, it is expected to be flexible, hydrophilic, and conformationally adaptable.
Reactivity: The azide group is suitable for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling efficient conjugation under mild conditions. The tert-butyl esters can be cleaved using standard acid-labile conditions to reveal carboxylic acids for subsequent amide-forming couplings. Typical synthesis employs inert atmospheres when needed, polar aprotic solvents for coupling steps, and appropriate base or activating reagents consistent with amide-bond formation mechanisms.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
