N-(Biotin-PEG4)-N-bis(PEG4-Boc)
CAS No.: 2112730-79-5
Cat No.: BP-501063
4.5 
N-(Biotin-PEG4)-N-bis(PEG4-Boc) is a biotin-functionalized, multi–poly(ethylene glycol) (PEG) linker designed for PROTAC and targeted protein degradation workflows that require controlled conjugation and handleable sterics. Structurally, it contains a biotin moiety connected through a PEG4 spacer to a central tertiary amine, which is further substituted with two PEG4 arms bearing tert-butyl ester-protected carboxylic acid termini. The PEG segments provide aqueous solubility and flexible reach, while the tert-butyl esters protect two carboxylic acid handles that can be deprotected, activated, and coupled to complementary ligands. In PROTAC design, this linker serves as a modular scaffold that can spatially tune the distance and orientation between binding components, facilitating productive ternary complex formation and improving degradation efficiency in linker-sensitive systems. Its biotin handle also supports affinity-based detection, purification, and immobilization during optimization of degradation constructs.
Structure of 2112730-79-5
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This PROTAC linker reagent, N-(Biotin-PEG4)-N-bis(PEG4-Boc), is designed to provide a flexible polyethylene glycol (PEG) spacer architecture that supports efficient conjugation and subsequent assembly of targeted protein degraders. Its biotin handle enables affinity-based workflows for material handling, while tert-butyl ester-protected carboxyl termini facilitate controlled functional-group unveiling during PROTAC synthesis. The following sections describe the linker’s structural features and practical reactivity considerations in detail.
Structure: The molecule contains a biotin-derived moiety connected through a PEG-based chain, with additional PEG4 segments bearing tert-butyl ester-protected carboxyl groups. It features ether linkages within the PEG scaffold and tert-butyl ester protection, yielding a polar, water-compatible, conformationally flexible linker suitable for PROTAC architectures.
Reactivity: The tert-butyl esters are typically cleaved under acidic conditions to reveal carboxylic acids for coupling to amine-bearing ligands or other PROTAC fragments. The resulting carboxylic acids can be used in standard amide-forming conjugation strategies, commonly employing coupling reagents and appropriate bases in polar organic solvents. The PEG backbone generally enhances solubility and reduces steric constraints during assembly, supporting stepwise linker-to-ligand construction.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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