N-Boc-PEG24-alcohol
Cat No.: BP-501835
4.5 
N-Boc-PEG24-alcohol is a polyethylene glycol (PEG) linker bearing a terminal primary alcohol and a Boc-protected group, providing a hydrophilic, flexible spacer with a long ethylene glycol chain that can reduce steric interference in multicomponent PROTAC constructs. The PEG segment acts as an entropic “molecular cushion,” helping to position the two binding partners (typically an E3 ligase ligand and a target-binding moiety) to enable productive formation of the ternary complex. The terminal alcohol functionality enables straightforward derivatization to reactive handles (for example, esterification or ether formation) for conjugation to warheads or ligase recruiters, while the Boc group offers a protected amine for controlled coupling strategies. In targeted protein degradation research, such PEG-based linkers are widely used to tune linker length, solubility, and conformational dynamics, which can strongly influence degradation potency and cellular activity by optimizing effective proximity and engagement of the recruited proteins.
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* For research and manufacturing use only. Not for human or clinical use.
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N-Boc-PEG24-alcohol is a protected, hydrophilic polyethylene glycol linker designed to support PROTAC assembly by providing a stable handle for conjugation and subsequent deprotection. Its PEG-rich chain promotes solubility and flexible spatial presentation between the target-binding ligand and the E3 ligase recruiter, which can improve productive ternary complex formation. This molecule will be described in detail below, including its structural features and practical considerations for PROTAC linker integration.
Structure: The linker combines a terminal alcohol with a long, repeating ethylene glycol motif, imparting strong hydrogen-bonding capacity and high hydrophilicity. A Boc-protected amine functionality provides a stable carbamate linkage during coupling steps, while the PEG backbone offers conformational flexibility and ether-rich connectivity.
Reactivity: PROTAC construction typically uses the terminal alcohol for ester or ether formation with activated carboxylic acids or electrophilic linker derivatives, while the Boc group remains compatible with many standard coupling conditions. Subsequent Boc removal is commonly achieved under mild acid-promoted deprotection to reveal an amine for further amide coupling or urea/carbamate linkage formation. Solvent systems that dissolve PEG linkers (such as polar organic media) and coupling reagents suited to amine–acid or alcohol–activated ester chemistry are generally employed.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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