Name: Propargyl-PEG4-S-PEG4-Boc
Brand: BOC Sciences
Rating: 5 (1 reviews)

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$--

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Purity

98%

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Synonyms

Propargyl-PEG4-S-PEG4-t-butyl ester

InChI Key

CQWOCVRYLDFSFI-UHFFFAOYSA-N

InChI

InChI=1S/C26H48O10S/c1-5-7-28-9-11-30-13-15-32-17-19-34-21-23-37-24-22-35-20-18-33-16-14-31-12-10-29-8-6-25(27)36-26(2,3)4/h1H,6-24H2,2-4H3

SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCOCCSCCOCCOCCOCCOCC#C

This extended heterobifunctional linker couples a terminal alkyne and protected carboxyl group through ether-rich segments containing a central thioether. It enables click-first or amidation-first PROTAC assembly and offers substantial conformational reach. Its structural and reactive properties are detailed below.

Structure: Oligoether segments flank a central thioether and terminate in a propargyl ether and tert-butyl propanoate. The molecule contains a terminal alkyne, numerous ether bonds, a sulfur-containing single bond, and an ester carbonyl, creating a flexible and polarizable linear spacer.

Reactivity: The alkyne undergoes cuprous-catalyzed cycloaddition with an azide in a compatible polar solvent using a stabilizing ligand and reductant. Because sulfur can coordinate metals and undergo oxidation, catalyst loading and oxidative exposure should be controlled. Acidic ester cleavage then provides a carboxylic acid for activated amide coupling with an amine-bearing ligand under standard anhydrous, mildly basic conditions.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂