NH2-PEG1-CH2COOtBu
CAS No.: 1155811-37-2
Cat No.: BP-500358
Purity: ≥95%
4.5 
NH2-PEG1-CH2COOtBu is a short, amino-terminated polyethylene glycol linker bearing a terminal protected carboxylate, designed to provide a flexible hydrophilic spacer between PROTAC-relevant fragments. Structurally, it contains a single ethylene glycol unit that confers conformational mobility and reduces steric interference, while the primary amine enables straightforward coupling to activated carboxylic acids, isocyanates, or other electrophiles used to assemble PROTAC architectures. The CH2COOtBu group serves as a protected handle for subsequent deprotection to reveal a carboxylic acid, allowing amide or ester bond formation with ligands or other linker segments. In PROTAC design, such PEG-based spacers can improve effective proximity and productive orientation between the target-binding moiety and the E3 ligase recruiter, often enhancing degradation performance by mitigating unfavorable intramolecular constraints. This linker is therefore valuable for constructing modular, chemically tractable conjugates for targeted protein degradation studies.
Structure of 1155811-37-2
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This PEG-based linker is designed to connect a ligand for a target protein to an E3 ligase recruiter in PROTAC constructs, providing a flexible, hydrophilic spacer that can help tune effective intramolecular geometry and solubility. Its ether-rich backbone and terminal functional group support modular synthesis under standard organic conditions. The following sections describe the linker’s structural features and practical reactivity considerations for assembling PROTACs, including compatible coupling strategies and reaction design principles.
Structure: The linker contains a poly(ethylene glycol) segment with ether linkages, providing conformational flexibility and strong water compatibility. It bears a primary amine and a protected carboxylate functionality, with an alkyl spacer that supports controlled distance between conjugation handles.
Reactivity: The primary amine enables amide or urea formation via activated carboxylic acid derivatives, such as acid chlorides, activated esters, or coupling reagents commonly used in peptide/bioconjugation chemistry. The tert-butyl-protected carboxylate can be deprotected under acid conditions to reveal a free acid for subsequent coupling. Typical workflows use polar aprotic solvents and base/activator systems, with reaction temperatures and times optimized to preserve sensitive ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
