Name: dTAGV-1 TFA
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPACName

[(1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[7-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-7-oxoheptyl]amino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate;2,2,2-trifluoroacetic acid

InChI Key

KSEWNBIDXKMTNT-LNVAYBNASA-N

InChI

InChI=1S/C68H90N6O14S.C2HF3O2/c1-12-49(47-36-57(84-9)61(86-11)58(37-47)85-10)65(79)73-34-20-18-22-51(73)67(81)88-54(31-25-44-26-32-55(82-7)56(35-44)83-8)50-21-16-17-23-53(50)87-40-60(77)69-33-19-14-13-15-24-59(76)72-63(68(4,5)6)66(80)74-39-48(75)38-52(74)64(78)71-42(2)45-27-29-46(30-28-45)62-43(3)70-41-89-62;3-2(4,5)1(6)7/h16-17,21,23,26-30,32,35-37,41-42,48-49,51-52,54,63,75H,12-15,18-20,22,24-25,31,33-34,38-40H2,1-11H3,(H,69,77)(H,71,78)(H,72,76);(H,6,7)/t42-,48+,49-,51-,52-,54+,63+;/m0./s1

SMILES

CCC(C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCCC2C(=O)OC(CCC3=CC(=C(C=C3)OC)OC)C4=CC=CC=C4OCC(=O)NCCCCCCC(=O)NC(C(=O)N5CC(CC5C(=O)NC(C)C6=CC=C(C=C6)C7=C(N=CS7)C)O)C(C)(C)C.C(=O)(C(F)(F)F)O

Mechanism

Target: Targets FKBP12 or FKBP12F36V degradation-tag fusion proteins for experimental targeted protein degradation studies.

Binding Site: Binds the FKBP12 ligand pocket and recruited E3 ligase substrate-recognition domain to support productive ternary complex formation.

Mechanism of Action: dTAGV-1 TFA is designed for use in PROTAC or targeted protein degradation experiments directed toward FKBP12 or FKBP12F36V degradation-tag fusion proteins. The bifunctional molecule links a target-recognition element to VHL, promoting proximity between the protein of interest and ubiquitination machinery. Productive ternary-complex formation can drive polyubiquitination and proteasome-dependent target depletion, allowing researchers to compare pharmacological inhibition with protein removal. It is suitable for evaluating degradation potency, kinetics, pathway selectivity, and downstream signaling consequences in engineered or disease-relevant cellular models.

Applications

• PROTAC-Mediated Targeted Degradation: dTAGV-1 TFA is a powerful tool in the study of targeted protein degradation, enabling researchers to selectively degrade proteins of interest. This facilitates the investigation of protein function and the elucidation of cellular pathways, providing insights into complex biological processes.

• Protein Function Analysis via PROTAC: Utilizing dTAGV-1 TFA, scientists can achieve precise control over protein levels, offering a dynamic approach to study the consequences of protein depletion in cellular models. This enhances our understanding of protein roles in various biological contexts.

• Cellular Pathway Dissection through PROTACs: dTAGV-1 TFA aids in dissecting cellular pathways by allowing the selective removal of key regulatory proteins. This targeted degradation approach is instrumental in mapping out signaling networks and identifying potential therapeutic targets.

• PROTAC-Driven Research in Disease Models: The application of dTAGV-1 TFA in disease models enables the exploration of pathogenic mechanisms through the targeted degradation of disease-relevant proteins. This contributes to the identification of novel intervention points for therapeutic development.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂