PEG7-O-Ms

PEG7-O-Ms is a polyethylene glycol-based mesylate linker designed for efficient, modular attachment of PROTAC components. Its solubilizing PEG character supports favorable handling and aqueous compatibility, while the mesylate leaving group enables reliable formation of ether or related linkages under standard synthetic conditions. As a versatile building block, it facilitates the construction of targeted protein degradation molecules by linking ligands through stable covalent bonds;

Structure: PEG7-O-Ms comprises a poly(ethylene glycol) chain bearing an O-mesylate functionality. The mesylate group is an arylsulfonate ester featuring a sulfonyl-oxygen bond, while the PEG segment provides flexible ether linkages. This combination yields a polar, ether-rich scaffold with enhanced solubility and conformational mobility.

Reactivity: The mesylate ester serves as an activated electrophile for nucleophilic substitution, enabling installation of PROTAC linkages via SN2-type displacement by oxygen or nitrogen nucleophiles. Typical conditions employ polar aprotic or mixed solvent systems with base to generate the nucleophile, while temperature and time are selected to balance substitution efficiency and minimize side reactions. No special catalysts are generally required beyond standard base-mediated coupling protocols.