Name: m-PEG3-S-PEG3-Boc
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]propanoate

InChI Key

HPUREYBEJCEQQQ-UHFFFAOYSA-N

InChI

InChI=1S/C20H40O8S/c1-20(2,3)28-19(21)5-6-23-9-10-25-12-14-27-16-18-29-17-15-26-13-11-24-8-7-22-4/h5-18H2,1-4H3

SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCSCCOCCOCCOC

This m-PEG3-S-PEG3-Boc linker is designed to connect PROTAC-binding modules through a PEG-based, thioether-containing scaffold that supports conformational flexibility and improved solubility. Its Boc-protected functionality enables controlled downstream functionalization, facilitating the modular assembly of targeted protein degraders. The linker’s architecture is well suited for constructing conjugates that maintain productive geometry between ligands and the recruited E3 machinery.

Structure: The linker comprises PEG oligomer segments linked through a thioether (sulfide) and incorporates a Boc-protected functional group. It contains ether linkages within the PEG chains, flexible C–O and C–S connectivity, and a carbamate motif from the Boc group. Overall, it is expected to be polar and water-compatible.

Reactivity: Boc-protected sites are typically introduced or manipulated using acid-mediated deprotection, followed by coupling to appropriate ligand handles. The thioether linkage is generally stable under mild conditions, supporting stepwise PROTAC synthesis. For conjugation, standard amide or carbamate-forming chemistries can be applied after deprotection, using common coupling reagents and polar aprotic solvents, while maintaining conditions that preserve PEG integrity and the sulfide linkage.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂