Pomalidomide-linker 1

 CAS No.: 2245697-87-2  Cat No.: BP-100054  Purity: ≥98% 4.5  

Pomalidomide-linker 1 is a crosslinker−E3 ligase ligand conjugate composed of a cereblon-recuiting ligand pomalidomide and a PEGylated crosslinker. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Pomalidomide-linker 1

Structure of 2245697-87-2

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C19H24N4O6.HCl
Molecular Weight
440.88

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥98%
ShelfLife
2 years
Storage
-20°C
Synonyms
4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
InChI Key
BIBZEYIXXZHGNZ-UHFFFAOYSA-N
InChI
InChI=1S/C19H24N4O6.ClH/c20-6-8-28-10-11-29-9-7-21-13-3-1-2-12-16(13)19(27)23(18(12)26)14-4-5-15(24)22-17(14)25;/h1-3,14,21H,4-11,20H2,(H,22,24,25);1H
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCN.Cl

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: SIM1 | Hydroxy-PEG1-t-butyl ester | Pomalidomide-C6-PEG3-butyl azide | Pomalidomide-C6-COOH | MD-224 | Bis-PEG4-acid | Amino-PEG3-propionic acid | Amino-PEG3-amine | Cytochalasin J | 2-Bromoethyl ether | Pomalidomide-linker 1

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