Pomalidomide-PEG1-C2-NH2

 CAS No.: 2138439-12-8  Cat No.: BP-100165  Purity: ≥95% 4.5  

Pomalidomide-PEG1-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Pomalidomide-PEG1-C2-NH2

Structure of 2138439-12-8

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C17H20N4O5
Molecular Weight
360.36
Appearance
White to Off-white Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Appearance
White to Off-white Solid
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
IUPACName
4-[2-(2-aminoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonyms
Thalidomide-NH-PEG1-NH2; 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
Boiling Point
660.5±55.0°C at 760 mmHg
Density
1.4±0.1 g/cm3
InChI Key
WEPAAESBMNSHJA-UHFFFAOYSA-N
InChI
InChI=1S/C17H20N4O5/c18-6-8-26-9-7-19-11-3-1-2-10-14(11)17(25)21(16(10)24)12-4-5-13(22)20-15(12)23/h1-3,12,19H,4-9,18H2,(H,20,22,23)
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCN

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

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