Pomalidomide-PEG1-C2-N3

 CAS No.: 2271036-44-1  Cat No.: BP-100101 4.5  

Pomalidomide-PEG1-C2-N3 is a synthetic E3 ligand-linker sonjugate containing a Pomalidomide-based cereblon ligand and a PEG linker with a O(CH2)2 monnomer, which is an intermediate in the synthesis of PROTAC degradation agent induces CDK6 degradation with a DC50 of 2.1 nM.

Pomalidomide-PEG1-C2-N3

Structure of 2271036-44-1

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E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C₁₇H₁₈N₆O₅
Molecular Weight
386.36

* For research and manufacturing use only. Not for human or clinical use.

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Storage
-20°C, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
4-[2-(2-azidoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonyms
Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50
InChI Key
NJPMWHWTBBYBDY-UHFFFAOYSA-N
InChI
1S/C17H18N6O5/c18-22-20-7-9-28-8-6-19-11-3-1-2-10-14(11)17(27)23(16(10)26)12-4-5-13(24)21-15(12)25/h1-3,12,19H,4-9H2,(H,21,24,25)
Canonical SMILES
[N-]=[N+]=NCCOCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O
Pub Chem ID
138857982

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: PROTAC Sirt2 Degrader-1 | PROTAC BET degrader-2 | 3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione | AVL-292 | PROTAC B-Raf degrader 1 | PROTAC CDK9 Degrader-1 | FF-10101 | Ald-Ph-PEG24-NHS ester | BSJ-03-123 | Thalidomide | Pomalidomide-PEG1-C2-N3

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