Propargyl-PEG8-NHBoc
CAS No.: 2183440-31-3
Cat No.: BP-500609
Purity: ≥95%
4.5 
Propargyl-PEG8-NHBoc is a polyethylene glycol (PEG) based PROTAC linker featuring a terminal propargyl group for orthogonal chemical conjugation and an N-Boc-protected amine for controlled coupling chemistry. The PEG8 chain provides a flexible, hydrophilic spacer that can reduce steric interference between a target-binding ligand and an E3 ligase recruiter, while also improving solubility and maintaining productive ternary-complex formation. In targeted protein degradation workflows, this linker is typically used to connect functional warheads through bioorthogonal reactions (e.g., copper-catalyzed azide–alkyne cycloaddition when paired with an azide handle) or to enable subsequent derivatization of the protected amine after deprotection. Its modular design supports systematic optimization of linker length and attachment geometry, which are key determinants of degradation potency, selectivity, and cellular uptake in PROTAC development.
Structure of 2183440-31-3
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Propargyl-PEG8-NHBoc is a PEG-based PROTAC linker designed to provide a hydrophilic, conformationally flexible spacer that improves productive ternary complex formation while enabling orthogonal functionalization. Its propargyl handle supports bioorthogonal conjugation strategies, and the protected amine (NHBoc) offers controlled coupling chemistry during PROTAC assembly. The combination of a polyethylene glycol backbone and protected reactive functionality makes this linker well suited for constructing targeted protein degraders;
Structure: The molecule comprises a polyethylene glycol segment that confers flexibility and water compatibility, terminating in a propargyl group and a Boc-protected amine. It contains ether linkages along the PEG chain, a carbon–carbon triple bond in the propargyl moiety, and carbamate functionality from the Boc group.
Reactivity: The propargyl group enables alkyne-selective conjugation commonly used in PROTAC workflows, including copper-catalyzed azide–alkyne cycloaddition or related alkyne coupling approaches under mild conditions. The Boc-protected amine is typically introduced or retained during earlier steps and later deprotected using standard acidolysis to generate a reactive amine for amide or urea bond formation. Suitable solvents are those compatible with both protection/deprotection and coupling chemistries, with catalysts selected according to the chosen alkyne reaction.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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