SirReal1-O-propargyl

 CAS No.: 1862237-99-7  Cat No.: BP-300013 4.5  

SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2.

SirReal1-O-propargyl

Structure of 1862237-99-7

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Ligand for Target Protein
Molecular Formula
C21H20N4O2S2
Molecular Weight
424.54

* For research and manufacturing use only. Not for human or clinical use.

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Solubility
10 mM in DMSO;H2O : ≥ 150 mg/mL
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere
Synonyms
SirReal1-O-propargyl; PROTAC Sirt2-binding moiety 1; 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(3-(prop-2-yn-1-yloxy)benzyl)thiazol-2-yl)acetamide
Canonical SMILES
O=C(NC1=NC=C(CC2=CC=CC(OCC#C)=C2)S1)CSC3=NC(C)=CC(C)=N3

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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: (S,R,S)-AHPC (TFA) | (S,S,S)-AHPC hydrochloride | Pomalidomide-PEG2-butyl iodide | 3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol | GNF5-amido-Me | Afimoxifene | dBRD9 | dBET6 | 3,6,9,12,15,18,21,24,27,30-Decaoxatritriacont-32-yn-1-ol | CMP 98 | SirReal1-O-propargyl

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