Name: t-Boc-N-amido-PEG1-acetic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Price

Stock

Quantity

$--

In stock

Purity

98%

Appearance

Colorless to light yellow solid

Storage

Store at -20 °C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]acetic acid

Synonyms

2-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethoxy]acetic acid; 2-(2-((tert-Butoxycarbonyl)amino)ethoxy)acetic acid; 2-(2-[[(tert-Butoxy)carbonyl]amino]ethoxy)acetic acid; 2-[2-[(2-Methylpropan-2-yl)oxycarbonylamino]ethoxy]acetic acid; Boc-5-amino-3-oxapentanoic acid; Boc-2-(2-aminoethoxy)acetic acid; 5-(t-Butyloxycarbonyl-amino)-3-oxapentanoic acid; Boc-AEA; N-Boc-2-(2-aminoethoxy)acetic Acid; t-Boc-N-amido-PEG1-CH2CO2H; (2-Boc-Aminoethoxy)acetic acid; BocNH-PEG1-acid

Boiling Point

391.2±22.0 °C at 760 mmHg

Density

1.151±0.06 g/cm3

InChI Key

UPBQMAHYLWJGDW-UHFFFAOYSA-N

InChI

InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-4-5-14-6-7(11)12/h4-6H2,1-3H3,(H,10,13)(H,11,12)

SMILES

CC(C)(C)OC(=O)NCCOCC(=O)O

This t-Boc-N-amido-PEG1-acetic acid linker is designed for constructing PROTAC architectures that require a chemically addressable, amide-bearing PEG element to tune solubility and spatial presentation of binding motifs. Its protected amine functionality enables stepwise conjugation strategies, while the carboxylic acid provides a reliable handle for coupling to targeting ligands. The following sections describe its structure and practical reactivity considerations in detail.

Structure: The molecule contains a tert-butoxycarbonyl-protected amide-forming nitrogen linked to a short ethylene glycol unit and a terminal acetic acid moiety. It features stable amide and ether linkages, with a Boc carbamate that can be removed under controlled conditions. Overall polarity supports aqueous compatibility.

Reactivity: The Boc-protected amine supports orthogonal, stepwise synthesis: deprotection followed by amide bond formation to attach PROTAC ligands. Carboxylic acid coupling is typically performed using standard peptide-coupling reagents under mild base conditions in polar organic solvents, forming robust amide linkages via activation of the acid. Careful control of pH and protecting-group stability helps preserve the linker during sequential assembly.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂