Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

 CAS No.: 175724-30-8  Cat No.: BP-501300  Purity: >98.0%  HNMR  MS 4.5  

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

Structure of 175724-30-8

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Category
PROTAC Linker
Molecular Formula
C25H47NO9
Molecular Weight
505.64
Appearance
Colourless oil

* For research and manufacturing use only. Not for human or clinical use.

SizePriceStockQuantity
5 g $1573 In stock

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Purity
>98.0%
Solubility
10 mm in DMSO
Appearance
Colourless oil
ShelfLife
-20°C 3 years powder; -80°C 2 years in solvent
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Shipping
Room temperature, or blue ice upon request.
IUPACName
tert-butyl 3-[2-amino-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]-2-[[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]methyl]propoxy]propanoate
Synonyms
Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane; tert-butyl 3,3'-(2-amino-2-((3-tert-butoxy-3-oxopropoxy)methyl)propane-1,3-diyl)bis(oxy)dipropanoate
InChI Key
KPXODPHVWBQJEG-UHFFFAOYSA-N
InChI
InChI=1S/C25H47NO9/c1-22(2,3)33-19(27)10-13-30-16-25(26,17-31-14-11-20(28)34-23(4,5)6)18-32-15-12-21(29)35-24(7,8)9/h10-18,26H2,1-9H3
Canonical SMILES
CC(C)(C)OC(=O)CCOCC(COCCC(=O)OC(C)(C)C)(COCCC(=O)OC(C)(C)C)N

How does Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine selectively degrade target proteins?

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

21/12/2019

synthesize antibody-drug conjugates (ADCs)

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is used in the synthesis of antibody-drug conjugates (ADCs) in my experiment. The quality is very good.

14/4/2018

synthesize PROTACs

We used Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine to synthesize PROTACs. The purity is very high.

22/7/2019

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

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