Name: t-Boc-N-Amido-PEG3-Amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>98%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow Oily Liquid

Storage

Store at 2-8°C under inert gas (nitrogen or Argon)

Shipping

Room temperature in continental US; may vary elsewhere

IUPACName

tert-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate

Synonyms

NHBoc-PEG3-amine; 5,8,11-Trioxa-2-azatridecanoic, 13-amino-, 1,1-dimethylethyl ester; BOC-NH-PEG3-NH2; tert-Butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate; N-Boc-1,11-diamino-3,6,9-trioxaundecane; tert-Boc-N-amido-PEG3-amine; Boc-N-Amido-PEG3-Amine; N-Boc-2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanamine; 1-Boc-amino-11-bromo-3,6,9-trioxadecane; Carbamic acid, N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl (2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)carbamate

Boiling Point

405.7±35.0 °C at 760 mmHg

Density

1.05 g/cm<sup>3</sup>

InChI Key

CUPBLDPRUBNAIE-UHFFFAOYSA-N

InChI

InChI=1S/C13H28N2O5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11,14H2,1-3H3,(H,15,16)

SMILES

CC(C)(C)OC(=O)NCCOCCOCCOCCN

t-Boc-N-Amido-PEG3-Amine, is designed to provide a flexible polyethylene glycol spacer with an amine handle for controlled conjugation. Its amide-bearing connectivity and protected amine enable stepwise assembly of bifunctional degraders, supporting reliable linker installation and minimizing undesired side reactions. The subsequent sections describe the structural features and practical reactivity considerations for constructing PROTACs using this linker.

Structure: The molecule contains a Boc-protected amine, a PEG-based ethylene glycol segment, and an amide linkage that together confer conformational flexibility and improved solubility. It features stable covalent C–N and C–O bonds, with a carbamate (Boc) protecting group and an amide carbonyl providing defined hydrogen-bonding characteristics.

Reactivity: The Boc group can be removed under standard acid-mediated deprotection conditions to reveal the primary amine for coupling. PROTAC assembly commonly employs amine-reactive electrophiles (e.g., activated esters, isocyanates, or sulfonyl derivatives) to form stable amide or related linkages. Typical workflows use polar aprotic solvents, base-assisted activation where appropriate, and temperature control to preserve sensitive functional groups on targeting ligands.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂