t-Boc-N-amido-PEG4-amine

 CAS No.: 811442-84-9  Cat No.: BP-500094  Purity: ≥95% 4.5  

t-Boc-N-amido-PEG4-amine is a protected PEG linker with an amine functionality, useful in ADC synthesis. The Boc group ensures selective deprotection, enabling precise linker assembly, while PEG4 spacing improves solubility and flexibility of antibody-drug conjugates.

t-Boc-N-amido-PEG4-amine

Structure of 811442-84-9

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Category
PROTAC Linker
Molecular Formula
C15H32N2O6
Molecular Weight
336.42
Appearance
Pale Yellow or Colorless Oily Liquid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance
Pale Yellow or Colorless Oily Liquid
Storage
Store at 2-8°C, protect from light
Shipping
Room temperature
IUPACName
tert-butyl N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate
Synonyms
Boc-NH-PEG4-CH2CH2NH2; NHBoc-PEG4-amine; O-(2-Aminoethyl)-O'-[2-(Boc-amino)ethyl]triethylene Glycol; 16-Amino-5,8,11,14-tetraoxa-2-azahexadecanoic Acid 1,1-Dimethylethyl Ester; tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate; N1-Boc-3,6,9,12-tetraoxatetradecane-1,14-diamine; BocNH-PEG4-NH2; 5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-amino-, 1,1-dimethylethyl ester
Boiling Point
443.9±40.0 °C at 760 mmHg
Density
1.059±0.06 g/cm3 (Predicted)
InChI Key
WCNWLERBLMBSOT-UHFFFAOYSA-N
InChI
InChI=1S/C15H32N2O6/c1-15(2,3)23-14(18)17-5-7-20-9-11-22-13-12-21-10-8-19-6-4-16/h4-13,16H2,1-3H3,(H,17,18)
Canonical SMILES
CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN
Biological Activity
Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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