Name: TCO-PEG8-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

98%

Solubility

DMSO, DCM, DMF

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

[(4Z)-cyclooct-4-en-1-yl] N-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate

Synonyms

Cyclooct-4-en-1-yl (26-amino-3,6,9,12,15,18,21,24-octaoxahexacosyl)carbamate; (E)-Cyclooct-4-en-1-yl (26-amino-3,6,9,12,15,18,21,24-octaoxahexacosyl)carbamate; (4Z)-cyclooct-4-en-1-yl N-(26-amino-3,6,9,12,15,18,21,24-octaoxahexacosan-1-yl)carbamate

InChI Key

MXEGVNVGOKEYSH-UPHRSURJSA-N

InChI

InChI=1S/C27H52N2O10/c28-8-10-31-12-14-33-16-18-35-20-22-37-24-25-38-23-21-36-19-17-34-15-13-32-11-9-29-27(30)39-26-6-4-2-1-3-5-7-26/h1-2,26H,3-25,28H2,(H,29,30)/b2-1-

SMILES

C1CC=CCCC(C1)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN

TCO-PEG8-amine is a polyethylene glycol (PEG) based bifunctional linker designed for efficient conjugation in PROTAC workflows that employ trans-cyclooctene (TCO) chemistry. Its flexible PEG spacer supports productive ternary complex formation by improving linker solubility and conformational reach, while the terminal amine enables straightforward coupling to targeting ligands. The sections below describe its structure and practical reactivity considerations for constructing PROTACs.

Structure: The linker contains a PEG chain providing a hydrophilic, conformationally flexible spacer, terminating in a primary amine for conjugation. It features ether linkages characteristic of PEG, with a trans-cyclooctene motif that supports bioorthogonal reactivity. Overall, it is designed to enhance solubility and reduce nonspecific interactions.

Reactivity: TCO-PEG8-amine is typically used in PROTAC assembly via TCO-mediated bioorthogonal conjugation, where the TCO group reacts with a complementary tetrazine handle under mild conditions. The terminal amine can be employed for amide or urea-forming coupling to activated carboxylic acids or isocyanates, using standard peptide coupling chemistries. Reactions are commonly performed in aqueous-compatible buffers with appropriate base and coupling reagents to preserve TCO integrity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂