Name: t-Boc-N-amido-PEG6-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO (10 mm)

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at -20°C, keep in dry and avoid sunlight

Shipping

Room temperature

IUPACName

3-[2-[2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Boc-NH-PEG6-CH2CH2COOH; t-Boc-NH-amido-PEG6-COOH; Boc-NH-PEG6-COOH; t-Boc-N-amido-PEG6-acid; Boc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; 21-(Boc-amino)-4,7,10,13,16,19-hexaoxaheneicosanoic acid; 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azahexacosan-26-oic acid; 3,8,11,14,17,20,23-Heptaoxa-5-azahexacosan-26-oic acid, 2,2-dimethyl-4-oxo-; 21-[(tert-Butoxycarbonyl)amino]-4,7,10,13,16,19-hexaoxaheneicosanoic Acid; 5,8,11,14,17,20-Hexaoxa-2-azatricosanedioic acid 1-(1,1-dimethylethyl) ester

Boiling Point

568.1±50.0 °C at 760 mmHg

Density

1.123±0.06 g/cm3

InChI Key

FTTYOIHYERRXQB-UHFFFAOYSA-N

InChI

InChI=1S/C20H39NO10/c1-20(2,3)31-19(24)21-5-7-26-9-11-28-13-15-30-17-16-29-14-12-27-10-8-25-6-4-18(22)23/h4-17H2,1-3H3,(H,21,24)(H,22,23)

SMILES

CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)O

t-Boc-N-amido-PEG6-propionic acid, provides a polyethylene glycol spacer with a protected amide handle and a carboxylic acid for controlled conjugation. Its hydrophilic, flexible architecture supports favorable solubility and reduced steric bias in bifunctional degraders. The Boc-protected functionality enables stepwise assembly of PROTACs, facilitating reliable coupling to targeting ligands and E3-recruiting moieties. Detailed structural and synthetic considerations are provided below.

Structure: The linker contains a PEG-based polyether chain that confers conformational flexibility and hydrophilicity, flanked by an amide linkage and a terminal carboxylic acid. A Boc-protected nitrogen and amide carbonyl establish stable covalent connectivity, while ether oxygen atoms support hydrogen-bonding interactions.

Reactivity: The carboxylic acid can be activated for amide-bond formation using standard coupling chemistries, typically via carbodiimide or uronium-type activators with a base in polar aprotic solvents. The Boc group is removable under controlled acid conditions to reveal an amine for subsequent coupling. These steps enable modular PROTAC synthesis through sequential deprotection and bond formation, with purification by conventional chromatography or precipitation where appropriate.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂