Name: TAMRA-PEG3-biotin
Brand: BOC Sciences
Rating: 5 (1 reviews)

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$--

In stock

Purity

831.0

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3',6'-bis(dimethylamino)-3-oxo-N-[2-[2-[2-[2-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]ethoxy]ethoxy]ethoxy]ethyl]spiro[2-benzofuran-1,9'-xanthene]-5-carboxamide

Synonyms

TAMRA-PEG3-DL-biotin; N-(2-{2-[2-(2-{[3',6'-bis(dimethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanamide

InChI Key

BWYKRFATNNMLLL-UHFFFAOYSA-N

InChI

InChI=1S/C43H54N6O9S/c1-48(2)28-10-13-32-35(24-28)57-36-25-29(49(3)4)11-14-33(36)43(32)31-12-9-27(23-30(31)41(52)58-43)40(51)45-16-18-55-20-22-56-21-19-54-17-15-44-38(50)8-6-5-7-37-39-34(26-59-37)46-42(53)47-39/h9-14,23-25,34,37,39H,5-8,15-22,26H2,1-4H3,(H,44,50)(H,45,51)(H2,46,47,53)

SMILES

CN(C)C1=CC2=C(C=C1)C3(C4=C(C=C(C=C4)C(=O)NCCOCCOCCOCCNC(=O)CCCCC5C6C(CS5)NC(=O)N6)C(=O)O3)C7=C(O2)C=C(C=C7)N(C)C

TAMRA-PEG3-biotin is a bifunctional PEG-based linker designed for conjugation workflows commonly used in PROTAC research, enabling flexible spatial presentation of recognition and labeling motifs. Its PEG segment provides conformational flexibility and improved aqueous handling, while the biotin group supports affinity-based capture and downstream analytical or enrichment steps. The incorporated TAMRA fluorophore facilitates monitoring of conjugation efficiency and tracking of linker-containing species in mechanistic studies. Detailed structural and reactivity considerations are provided below.

Structure: TAMRA-PEG3-biotin combines a xanthene dye (TAMRA) with a short poly(ethylene glycol) spacer and a biotin moiety. The linker contains ether linkages within the PEG chain, amide or related conjugation-ready functionalities, and heteroatom-rich groups that enhance polarity and solubility in aqueous media.

Reactivity: Suitable PROTAC linker construction typically relies on orthogonal, chemoselective conjugation strategies that preserve dye and biotin integrity. Reaction schemes commonly employ activated carboxyl derivatives or amine-reactive intermediates to form stable amide or related bonds with partner ligands. Mild base or coupling conditions, compatible solvents such as polar aprotic media, and routine purification by chromatography are used to minimize fluorophore degradation. Affinity-based handling via biotin can support purification and verification steps during assembly.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂